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KMID : 0941820210310030180
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Korean Journal of Clinical Pharmacy
2021 Volume.31 No. 3 p.180 ~ p.187
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Arthralgia and Myalgia Associated with the Use of Bisphosphonate: An Active Monitoring Study
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Song Jung-Woo
Park So-Hee
Yoon Dong-Won
Lee Mo-Se
Lee Jung-Min
Kim Na-Young
Lee Ju-Yeon
Shin Ju-Young
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Abstract
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Objective: We investigated arthralgia and myalgia associated with the use of oral bisphosphonate (BP) by conducting a survey ofpatient.
Methods: The pharmacists conducted a survey between 1 Oct 2019 and 30 Sep 2020 among patients who were dispensed BPin community pharmacies to assess their demographic and medical characteristics, and their experiences with, and process for pain. Logistic regression analyses were performed to find the risk factors associated with the pain, and the odds ratios (OR) and 95%confidence intervals (CI) were determined.
Results: A total of 160 patients who used BP participated in the survey (74 [46.3%] usedrisedronate; 61 [38.1%] used alendronate; 23 [14.4%] used ibandronate), and 20 (12.5%) of them experienced pain. Significantstatistical differences of the characteristics between patients who experienced pain or not were observed regarding menopause, andparity. Compared with women who had one or two parity, women who had more than three parity were associated with the decreasedrisk of pain (OR, 0.24; 95% CI, 0.04-0.98). Moreover, steady exercise was associated with the decreased risk of pain compared toless exercise (OR, 0.37; 95% CI, 0.14-0.98).
Conclusion: Our findings suggest that the risk of pain in BP-treated patients might bedifferent regarding the different ingredients of BP, and dosing frequency. This survey highlights a need for a further safety research tounderstand the factors influencing the pain associated with the BP treatment.
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KEYWORD
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Adverse drug reaction, bisphosphonate, survey
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